ALS is a neurological disease that affects functioning of muscles adversely. In later stages, the disease may lead to complete paralysis.
Also called Lou Gehrig's Disease, ALS affects nerve cells in the brain and the spinal cord. Motor neurons that, under normal condition, travel from the brain to the spinal cord and from the spinal cord to the muscles throughout the body start degenerating. The progressive degeneration eventually leads to the death of these neurons and in their absence, the ability of the brain to control muscle movement is lost. With voluntary muscle action gradually affected, patients eventually suffer paralysis.
The condition does not affect all the muscles of the body. It affects motor neurons that provide voluntary movements (like a man’s effort to climb up and down the stairs) and power to muscles. Since muscles in the heart and digestive system are of a different kind and their function is not voluntary, but automatic, they do not get affected by ALS.
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The word a-myo-trophic has been derived from Greek language. "A" means no or negative. "Myo" refers to muscle, and "trophic" means nourishment. In short, it means "No muscle nourishment." When a muscle has no nourishment, it wastes away.
“Lateral" identifies the areas in a person's spinal cord where portions of the nerve cells that signal and control the muscles are located.
As this area degenerates, it leads to scarring or hardening ("sclerosis") in the region.
Early symptoms of ALS include increasing muscle weakness, especially involving the arms and legs, speech, swallowing or breathing. The limbs too become thinner.
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